Air Date: 12th October 2020
Guest: Dr. David T.W. Wong, DMD, DMSC, Felix & Mildred Yip Distinguished Professor, Associate Dean of Research and Director of the Oral/Head and Neck Oncology Research Center at UCLA; Fellow of the American Association for the Advancement of Sciences (AAAS), Fellow of AADR, past member of the ADA Council of Scientific Affairs and past president of American Association of Dental Research (AADR); currently chair of the NCI Liquid Biopsy Consortium and chartered member and co-chair of the NIH CSR Cancer Biomarker Study Section (CBSS).
- Dr. David T. W. Wong of UCLA is on the cutting edge of groundbreaking research in molecular diagnostics. On his biography page at UCLA, Wong describes the major research and discovery work he is doing in his laboratory.
“The ability to monitor for the early detection of cancer by non-invasive means,” writes Wong, “has been the holy grail for cancer researchers. However, progress towards this goal has not met expectations. My research group, with the support from NIDCR and NIH, has initiated a series of concerted efforts to spearhead the scientific and translational frontiers of salivary diagnostics. The potential use of saliva, a totally non-invasive biofluid, for oral and systemic disease detection, for disease progression, and for therapeutic monitoring are highly desirable goals. We have harnessed and defined five diagnostic alphabets from human saliva. In addition to the salivary proteome and salivary transcriptome, we have deciphered and defined the salivary micro-RNA, metabolome and microbiome. The availability of these diagnostic alphabets greatly enhanced the translational utility of saliva. In parallel to the biomarker efforts, we have been developing point-of-care technologies for using saliva for clinical diagnostics applications. The “Oral Fluid NanoSensor Test (OFNASET)” is a prototype nanotechnology point-of-care sensor that will have the ability to detect multiplex analytes in saliva for disease detection. The concurrent biomarker and technology development initiatives at UCLA led to the establishment of the UCLA Collaborative Oral Fluid Diagnostics Research Center to fully explore the scientific, translational and clinical frontiers of salivary diagnostics and salivary pharmacogenomics. The utilization of saliva for personalized individual medicine applications is only footsteps away.”
‘Only footsteps away’… “This news is incredibly exciting,” says Sharon Kleyne, host of the internationally syndicated The Power of Water® & Your Health sponsored by Nature’s Tears® EyeMist®, naturally pH balanced water technology for acid mantle protection, on VoiceAmerica World Talk Radio & Apple iTunes. “This is what drives scientific research,” Kleyne continues, “waking up every day and asking, ‘what will I learn today’.” This is why scientific research and discoveries are so vital to our health and wellbeing, and this is why health education needs to improve so that everyone can be more informed and more proactive about their health. Kleyne believes that dentists, for instance, must to do more to educate their patients about the oral cavity and its connection to immunity strength protection and weaknesses. “The research in Dr. Wong’s lab will lead to more rapid testing and identification of pathogens such as COVID-19,” says Kleyne. “The long-term goal is that in about three months a drop of saliva could concurrently and simultaneously evaluate if someone is infected with a virus as well as test immunity,” says Wong.
“The oral cavity is part of the body,” says Wong. “It communicates with the environment. Essential to every function such as mastication, speech and each body function is the production of saliva. There are three major saliva glands that collectively produce 600 millimeters of saliva on a daily basis. Saliva assists in digestion of food, aids capability of speech, and wards off pathogens. People with autoimmune problems don’t produce saliva; people exposed with radiation in the head and neck make less saliva.
“The portal entry of the pathogens to our bodies is the oral cavity and nasal cavity,” says Wong. “IGA antibodies exist in the mouth, offering protection, if you will. It is important to guard the portal entry to assist the mouth’s antibodies in fighting off pathogens such as the virus.”
Wong describes how sixteen years ago the National Institute of Health invested in the scientific community and posed a question. It asked researchers to scientifically credential saliva, a non-evasive material produced by our body that could be utilized for early disease detection. “The entire world is seeking early detection in the most non-evasive way. During this pandemic, half of research funding has been for saliva,” Wong reveals.
“This is why MAGA is so important—Masks Are Great Again—” says Kleyne. It’s just good common sense to wear a mask in public because it protects not only the wearer, but everyone else around her.”
If you care about immunity protection for the organ of the eyes, listen to these programs. They feature wisdom, knowledge, new technology and health tips for better living every week on the internationally syndicated The Power of Water® & Your Health sponsored by Nature’s Tears® EyeMist®, naturally pH balanced water technology for acid mantle protection on VoiceAmerica World Talk Radio & Apple iTunes with Program Director Rose Hong of Global Dragon TV with Sharon Kleyne.
LISTEN to the internationally syndicated The Power of Water® & Your Health sponsored by Nature’s Tears® EyeMist®, FDA approved, naturally pH balanced water technology for acid mantle protection, on VoiceAmerica World Talk Radio & Apple iTunes with producer and host Sharon Kleyne and program director Rose Hong of Global Dragon TV. This program features Dr. David T.W. Wong, DMD, DMSC.
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Some recent Sharon Kleyne talk radio programs feature:
Nancy Masiello & Kevin Kearns https://www.voiceamerica.com/episode/126115/common-sense-lessons-for-parents-and-children-getting-through-covid
Dr. David T.W. Wong, DMD, DMSC https://www.voiceamerica.com/episode/125933/saliva-diagnostics
Nancy Yonally Coleman & James Derick https://www.voiceamerica.com/episode/125837/be-safe-strategies-for-you-and-your-families-to-go-back-to-school-and-work-safely-during-covid
Dr. David Clarke https://www.voiceamerica.com/episode/125671/hidden-stresses-and-your-health
If you would like to watch a brief, entertaining educational film that demonstrates the application of the new Dry Eye Solution® technology Nature’s Tears® EyeMist®, sponsor of Sharon Kleyne’s talk radio program, go here: https://www.youtube.com/watch?v=l0gOr8TB45U
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